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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Id | http://purl.obolibrary.org/obo/NCIT_C1363
http://purl.obolibrary.org/obo/NCIT_C1363
|
|---|---|
| Preferred Name | Diaziquone |
| Definitions |
A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors. |
|---|---|
| label |
Diaziquone
|
| prefLabel |
Diaziquone
|
| Legacy Concept Name |
Diaziquone
|
| in_subset | |
| Preferred_Name |
Diaziquone
|
| Is_Value_For_GDC_Property | |
| Chemical_Formula |
C16H20N4O6
|
| Maps_To |
Diaziquone
|
| PDQ_Open_Trial_Search_ID |
39161
|
| UMLS_CUI |
C0113600
|
| FDA_UNII_Code |
FQL5EUP13W
|
| prefixIRI |
NCIT:C1363
|
| NCI_Drug_Dictionary_ID |
39161
|
| Contributing_Source |
FDA
|
| subClassOf | |
| code |
C1363
|
| type | |
| ALT_DEFINITION |
An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system.
|
| NSC Number |
182986
|
| PDQ_Closed_Trial_Search_ID |
39161
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| CAS_Registry |
57998-68-2
|
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