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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1363
http://purl.obolibrary.org/obo/NCIT_C1363
|
|---|---|
| Preferred Name | Diaziquone |
| Definitions |
A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors. |
|---|---|
| label | Diaziquone
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| prefLabel | Diaziquone
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| Legacy Concept Name | Diaziquone
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| in_subset | |
| Preferred_Name | Diaziquone
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C16H20N4O6
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| Maps_To | Diaziquone
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| PDQ_Open_Trial_Search_ID | 39161
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| UMLS_CUI | C0113600
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| FDA_UNII_Code | FQL5EUP13W
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| prefixIRI | NCIT:C1363
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| NCI_Drug_Dictionary_ID | 39161
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| Contributing_Source | FDA
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| subClassOf | |
| code | C1363
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| type | |
| ALT_DEFINITION | An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system.
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| NSC Number | 182986
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| PDQ_Closed_Trial_Search_ID | 39161
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 57998-68-2
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