Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1359
http://purl.obolibrary.org/obo/NCIT_C1359
|
|---|---|
| Preferred Name | Cyclopentenyl Cytosine |
| Definitions |
A pro-drug carbocyclic analogue of cytidine with antineoplastic and antiviral activities. Cyclopentenyl cytosine (CPEC) is converted to the active metabolite cyclopentenyl cytosine 5'-triphosphate (CPEC-TP); CPEC-TP competitively inhibits cytidine triphosphate (CTP) synthase, thereby depleting intracellular cytidine pools and inhibiting DNA and RNA synthesis. This agent may also induce differentiation of some tumor cell types. The antiviral activity of this agent is broad-spectrum.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A pro-drug carbocyclic analogue of cytidine with antineoplastic and antiviral activities. Cyclopentenyl cytosine (CPEC) is converted to the active metabolite cyclopentenyl cytosine 5'-triphosphate (CPEC-TP); CPEC-TP competitively inhibits cytidine triphosphate (CTP) synthase, thereby depleting intracellular cytidine pools and inhibiting DNA and RNA synthesis. This agent may also induce differentiation of some tumor cell types. The antiviral activity of this agent is broad-spectrum. |
|---|---|
| prefLabel | Cyclopentenyl Cytosine
|
| label | Cyclopentenyl Cytosine
|
| PDQ_Closed_Trial_Search_ID | 41433
|
| code | C1359
|
| prefixIRI | NCIT:C1359
|
| in_subset | |
| Preferred_Name | Cyclopentenyl Cytosine
|
| FDA_UNII_Code | 69MO0NDN8K
|
| Contributing_Source | FDA
|
| Maps_To | Cyclopentenyl Cytosine
|
| CAS_Registry | 90597-22-1
|
| NSC Number | 375575
|
| NCI_Drug_Dictionary_ID | 41433
|
| Legacy Concept Name | Cyclopentenyl_Cytosine
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41433
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
|
| UMLS_CUI | C0111606
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |