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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1350
http://purl.obolibrary.org/obo/NCIT_C1350
|
|---|---|
| Preferred Name | Beta-Thioguanine Deoxyriboside |
| Definitions |
A thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo. Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo. Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells. (NCI04) |
|---|---|
| prefLabel | Beta-Thioguanine Deoxyriboside
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| label | Beta-Thioguanine Deoxyriboside
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| PDQ_Closed_Trial_Search_ID | 39711
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| code | C1350
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| prefixIRI | NCIT:C1350
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| in_subset | |
| Preferred_Name | Beta-Thioguanine Deoxyriboside
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| FDA_UNII_Code | KR0RFB46DF
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| Contributing_Source | FDA
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| Maps_To | Beta-Thioguanine Deoxyriboside
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| CAS_Registry |
64039-27-6
789-61-7
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| NSC Number | 71261
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| NCI_Drug_Dictionary_ID | 39711
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| Legacy Concept Name | Beta-Thioguanine_Deoxyriboside
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39711
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0053376
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| Delete | Subject | Author | Type | Created |
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