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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1345
http://purl.obolibrary.org/obo/NCIT_C1345
|
|---|---|
| Preferred Name | Pamidronate Disodium |
| Definitions |
The disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation. |
|---|---|
| prefLabel | Pamidronate Disodium
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| label | Pamidronate Disodium
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| PDQ_Closed_Trial_Search_ID | 39149
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| code | C1345
|
| prefixIRI | NCIT:C1345
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| in_subset |
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| Display_Name | Pamidronate Disodium
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| Preferred_Name | Pamidronate Disodium
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| FDA_UNII_Code | 8742T8ZQZA
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C3H9NO7P2.2Na.5H2O
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| Maps_To | Pamidronate Disodium
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| CAS_Registry | 109552-15-0
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| NSC Number | 720699
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| NCI_Drug_Dictionary_ID | 39149
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| Legacy Concept Name | Pamidronate_Disodium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39149
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| Accepted_Therapeutic_Use_For | Hypercalcemia of malignancy; Osteolytic bone lesions of multiple myeloma; Osteolytic bone metastases of breast cancer; Pagets disease
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0356588
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