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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C133818
http://purl.obolibrary.org/obo/NCIT_C133818
|
|---|---|
| Preferred Name | Anti-AG7 Antibody Drug Conjugate AbGn-107 |
| Definitions |
An antibody drug conjugate (ADC) composed of a monoclonal antibody that targets the tumor-associated antigen (TAA) AG7 and is linked, through a hydrophilic, self-immolative linker, to a proprietary cytotoxic payload, with potential antineoplastic activity. Upon administration of AbGn-107 the antibody moiety targets and binds to the AG7 antigen expressed on a variety of cancer cells. Upon binding and internalization, the linker is cleaved and the payload is released, binds to tubulin, inhibits tubulin polymerization and kills the AG7-expressing tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antibody drug conjugate (ADC) composed of a monoclonal antibody that targets the tumor-associated antigen (TAA) AG7 and is linked, through a hydrophilic, self-immolative linker, to a proprietary cytotoxic payload, with potential antineoplastic activity. Upon administration of AbGn-107 the antibody moiety targets and binds to the AG7 antigen expressed on a variety of cancer cells. Upon binding and internalization, the linker is cleaved and the payload is released, binds to tubulin, inhibits tubulin polymerization and kills the AG7-expressing tumor cells. |
|---|---|
| prefLabel | Anti-AG7 Antibody Drug Conjugate AbGn-107
|
| label | Anti-AG7 Antibody Drug Conjugate AbGn-107
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| NCI_META_CUI | CL521740
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| PDQ_Closed_Trial_Search_ID | 789018
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| code | C133818
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| prefixIRI | NCIT:C133818
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| in_subset |
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| Display_Name | Anti-AG7 Antibody Drug Conjugate AbGn-107
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| Preferred_Name | Anti-AG7 Antibody Drug Conjugate AbGn-107
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| Contributing_Source | CTRP
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| Maps_To | Anti-AG7 Antibody Drug Conjugate AbGn-107
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| NCI_Drug_Dictionary_ID | 789018
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 789018
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| Semantic_Type | Pharmacologic Substance
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