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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1336
http://purl.obolibrary.org/obo/NCIT_C1336
|
|---|---|
| Preferred Name | Cladribine |
| Definitions |
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04) |
|---|---|
| prefLabel | Cladribine
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| label | Cladribine
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| CHEBI_ID | CHEBI:567361
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| PDQ_Closed_Trial_Search_ID | 41184
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| code | C1336
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| prefixIRI | NCIT:C1336
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| in_subset |
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| Display_Name | Cladribine
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| Preferred_Name | Cladribine
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| FDA_UNII_Code | 47M74X9YT5
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| Is_PCDC_AML_Permissible_Value_For_Variable | |
| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C10H12ClN5O3
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| Maps_To | Cladribine
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| CAS_Registry | 4291-63-8
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| NSC Number |
105014
105014-F
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| NCI_Drug_Dictionary_ID | 41184
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| Legacy Concept Name | Cladribine
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| DesignNote | |
| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antimetabolites.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41184
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| Accepted_Therapeutic_Use_For | Acute myeloid leukemia; Chronic lymphocytic leukemia; Cutaneous T-cell lymphoma; Hairy cell leukemia; Langerhans cell histiocytosis; Non-Hodgkins lymphoma; Waldenstroms macroglobulinemia
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0092801
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