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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C133174
http://purl.obolibrary.org/obo/NCIT_C133174
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|---|---|
| Preferred Name | Mcl-1 Inhibitor MIK665 |
| Definitions |
An inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MIK665 binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MIK665 binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival. |
|---|---|
| label | Mcl-1 Inhibitor MIK665
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| prefLabel | Mcl-1 Inhibitor MIK665
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| in_subset |
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| Preferred_Name | Mcl-1 Inhibitor MIK665
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| Is_Value_For_GDC_Property | |
| Display_Name | Mcl-1 Inhibitor MIK665
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| Maps_To | Mcl-1 Inhibitor MIK665
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| PDQ_Open_Trial_Search_ID | 788002
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| Has_Target | |
| FDA_UNII_Code | 801XYWHNOS
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| prefixIRI | NCIT:C133174
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| NCI_Drug_Dictionary_ID | 788002
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C133174
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| type | |
| PDQ_Closed_Trial_Search_ID | 788002
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 1799638-19-9
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| NCI_META_CUI | CL520448
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