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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1331
http://purl.obolibrary.org/obo/NCIT_C1331
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|---|---|
| Preferred Name | Epipodophyllotoxin Compound |
| Definitions |
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
|---|---|
| prefLabel | Epipodophyllotoxin Compound
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| label | Epipodophyllotoxin Compound
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| code | C1331
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| prefixIRI | NCIT:C1331
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| Preferred_Name | Epipodophyllotoxin Compound
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| Legacy Concept Name | Epipodophyllotoxin_Compound
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor.
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| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0086243
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