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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C131909
http://purl.obolibrary.org/obo/NCIT_C131909
|
|---|---|
| Preferred Name | EGFR T790M Antagonist BPI-15086 |
| Definitions |
An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M antagonist BPI-15086 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M antagonist BPI-15086 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. |
|---|---|
| prefLabel | EGFR T790M Antagonist BPI-15086
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| label | EGFR T790M Antagonist BPI-15086
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| NCI_META_CUI | CL520366
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| PDQ_Closed_Trial_Search_ID | 786371
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| code | C131909
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| Has_Target | |
| prefixIRI | NCIT:C131909
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| in_subset | |
| Preferred_Name | EGFR T790M Antagonist BPI-15086
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| Maps_To | EGFR T790M Antagonist BPI-15086
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| NCI_Drug_Dictionary_ID | 786371
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 786371
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| Semantic_Type | Pharmacologic Substance
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