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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C131821
http://purl.obolibrary.org/obo/NCIT_C131821
|
|---|---|
| Preferred Name | Iodine I 131 MIP-1095 |
| Definitions |
A radioconjugate composed of MIP-1095, a urea-based ligand for the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA) radiolabeled with iodine I 131 (I131), with potential antineoplastic activity. Upon administration of iodine I 131 MIP-1095, the MIP-1095 moiety selectively targets and binds to the extracellular domain of PSMA, thereby delivering cytotoxic iodine I 131 specifically to PSMA-expressing cancer cells. PSMA is a transmembrane glycoprotein that is highly expressed by malignant prostate epithelial cells and certain other tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioconjugate composed of MIP-1095, a urea-based ligand for the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA) radiolabeled with iodine I 131 (I131), with potential antineoplastic activity. Upon administration of iodine I 131 MIP-1095, the MIP-1095 moiety selectively targets and binds to the extracellular domain of PSMA, thereby delivering cytotoxic iodine I 131 specifically to PSMA-expressing cancer cells. PSMA is a transmembrane glycoprotein that is highly expressed by malignant prostate epithelial cells and certain other tumor cells. |
|---|---|
| prefLabel | Iodine I 131 MIP-1095
|
| label | Iodine I 131 MIP-1095
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| NCI_META_CUI | CL514422
|
| PDQ_Closed_Trial_Search_ID | 786538
|
| code | C131821
|
| Has_Target | |
| prefixIRI | NCIT:C131821
|
| in_subset |
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| Display_Name | Iodine I 131 MIP-1095
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| Preferred_Name | Iodine I 131 MIP-1095
|
| FDA_UNII_Code | 7DM27RQ9V0
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Iodine I 131 MIP-1095
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| CAS_Registry | 1258980-67-4
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| NCI_Drug_Dictionary_ID | 786538
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 786538
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| Semantic_Type | Pharmacologic Substance
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