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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C131572
http://purl.obolibrary.org/obo/NCIT_C131572
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|---|---|
| Preferred Name | Anti-CXCR4 Monoclonal Antibody PF-06747143 |
| Definitions |
A humanized immunoglobulin (Ig) G1 monoclonal antibody (mAb) against C-X-C chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration, anti-CXCR4 mAb PF-06747143 binds to CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation. This results in decreased proliferation and migration of CXCR4-expressing tumor cells. In addition, PF-06747143 promotes cell death through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family, is upregulated in several tumor cell types and plays an important role in cancer cell proliferation, survival, and chemotaxis, and in tumor angiogenesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized immunoglobulin (Ig) G1 monoclonal antibody (mAb) against C-X-C chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration, anti-CXCR4 mAb PF-06747143 binds to CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation. This results in decreased proliferation and migration of CXCR4-expressing tumor cells. In addition, PF-06747143 promotes cell death through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family, is upregulated in several tumor cell types and plays an important role in cancer cell proliferation, survival, and chemotaxis, and in tumor angiogenesis. |
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| prefLabel | Anti-CXCR4 Monoclonal Antibody PF-06747143
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| label | Anti-CXCR4 Monoclonal Antibody PF-06747143
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| NCI_META_CUI | CL514243
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| PDQ_Closed_Trial_Search_ID | 786269
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| code | C131572
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| Has_Target | |
| prefixIRI | NCIT:C131572
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| in_subset |
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| Display_Name | Anti-CXCR4 Monoclonal Antibody PF-06747143
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| Preferred_Name | Anti-CXCR4 Monoclonal Antibody PF-06747143
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| FDA_UNII_Code | 7TS9C20ZWA
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-CXCR4 Monoclonal Antibody PF-06747143
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| NCI_Drug_Dictionary_ID | 786269
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 786269
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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