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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C131534
http://purl.obolibrary.org/obo/NCIT_C131534
|
|---|---|
| Preferred Name | CXCR4 Antagonist USL311 |
| Definitions |
An orally bioavailable inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration, USL311 binds to CXCR4, thereby preventing the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation, which may result in decreased proliferation and migration of CXCR4-expressing tumor cells. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family, plays an important role in chemotaxis and angiogenesis, and is upregulated in several tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration, USL311 binds to CXCR4, thereby preventing the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation, which may result in decreased proliferation and migration of CXCR4-expressing tumor cells. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family, plays an important role in chemotaxis and angiogenesis, and is upregulated in several tumor cell types. |
|---|---|
| prefLabel | CXCR4 Antagonist USL311
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| label | CXCR4 Antagonist USL311
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| NCI_META_CUI | CL514455
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| PDQ_Closed_Trial_Search_ID | 786185
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| code | C131534
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| Has_Target | |
| prefixIRI | NCIT:C131534
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| in_subset |
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| Display_Name | CXCR4 Antagonist USL311
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| Preferred_Name | CXCR4 Antagonist USL311
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| FDA_UNII_Code | 2BTG5MX2Q2
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| Contributing_Source |
CTRP
FDA
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| Maps_To | CXCR4 Antagonist USL311
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| CAS_Registry | 1373268-67-7
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| NCI_Drug_Dictionary_ID | 786185
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 786185
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| Semantic_Type | Pharmacologic Substance
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