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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1314
http://purl.obolibrary.org/obo/NCIT_C1314
|
|---|---|
| Preferred Name | Trimetrexate |
| Definitions |
A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04) |
|---|---|
| prefLabel | Trimetrexate
|
| label | Trimetrexate
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| Has_Salt_Form | |
| code | C1314
|
| prefixIRI | NCIT:C1314
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| in_subset | |
| Preferred_Name | Trimetrexate
|
| FDA_UNII_Code | UPN4ITI8T4
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| Contributing_Source | FDA
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| Chemical_Formula | C19H23N5O3
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| Maps_To | Trimetrexate
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| CAS_Registry | 52128-35-5
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| NSC Number | 249008
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| Legacy Concept Name | Trimetrexate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0085176
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