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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C131368
http://purl.obolibrary.org/obo/NCIT_C131368
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|---|---|
| Preferred Name | Spherical Nucleic Acid Nanoparticle NU-0129 |
| Definitions |
A spherical nucleic acid (SNA) gold nanoparticle formulation composed of small interfering RNAs (siRNAs) targeting the Bcl-2-like protein 12 (BCL2L12) sequence and conjugated to gold nanoparticles, with potential antineoplastic activity. Upon administration of SNA NU-0129, the siRNA prevents the translation of the BCL2L12 gene. Inhibiting the expression of BCL2L12 by NU-0129 induces tumor cell apoptosis. Bcl2L12, a protein belonging to the Bcl-2 protein family, is overexpressed in glioblastoma multiforme (GBM) and plays a role in tumor cell progression and tumor cell resistance to apoptosis. NU-0129 is able to cross the blood brain barrier (BBB).
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A spherical nucleic acid (SNA) gold nanoparticle formulation composed of small interfering RNAs (siRNAs) targeting the Bcl-2-like protein 12 (BCL2L12) sequence and conjugated to gold nanoparticles, with potential antineoplastic activity. Upon administration of SNA NU-0129, the siRNA prevents the translation of the BCL2L12 gene. Inhibiting the expression of BCL2L12 by NU-0129 induces tumor cell apoptosis. Bcl2L12, a protein belonging to the Bcl-2 protein family, is overexpressed in glioblastoma multiforme (GBM) and plays a role in tumor cell progression and tumor cell resistance to apoptosis. NU-0129 is able to cross the blood brain barrier (BBB). |
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| prefLabel | Spherical Nucleic Acid Nanoparticle NU-0129
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| label | Spherical Nucleic Acid Nanoparticle NU-0129
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| NCI_META_CUI | CL514431
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| PDQ_Closed_Trial_Search_ID | 786841
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| code | C131368
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| Has_Target | |
| prefixIRI | NCIT:C131368
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| in_subset |
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| Display_Name | Spherical Nucleic Acid Nanoparticle NU-0129
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| Preferred_Name | Spherical Nucleic Acid Nanoparticle NU-0129
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| Contributing_Source | CTRP
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| Maps_To | Spherical Nucleic Acid Nanoparticle NU-0129
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| NCI_Drug_Dictionary_ID | 786841
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 786841
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| Semantic_Type | Pharmacologic Substance
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