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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1306
http://purl.obolibrary.org/obo/NCIT_C1306
|
|---|---|
| Preferred Name | O6-Benzylguanine |
| Definitions |
A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04) |
|---|---|
| prefLabel | O6-Benzylguanine
|
| label | O6-Benzylguanine
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| PDQ_Closed_Trial_Search_ID | 42113
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| code | C1306
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| Has_Target | |
| prefixIRI | NCIT:C1306
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| in_subset |
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| Display_Name | O6-Benzylguanine
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| Preferred_Name | O6-Benzylguanine
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| FDA_UNII_Code | 01KC87F8FE
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C12H11N5O
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| Maps_To | O6-Benzylguanine
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| CAS_Registry | 19916-73-5
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| NSC Number | 637037
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| NCI_Drug_Dictionary_ID | 42113
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| Legacy Concept Name | O_6_Benzylguanine
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| type | |
| ALT_DEFINITION | A drug that may improve the response of cancer cells to chemotherapy.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42113
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0083812
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| Delete | Subject | Author | Type | Created |
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