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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1301
http://purl.obolibrary.org/obo/NCIT_C1301
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|---|---|
| Preferred Name | Esperamicin A1 |
| Definitions |
An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora. The anthranilate component of esperamicin A1 intercalates DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-stranded breaks in DNA and apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora. The anthranilate component of esperamicin A1 intercalates DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-stranded breaks in DNA and apoptosis. (NCI04) |
|---|---|
| prefLabel | Esperamicin A1
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| label | Esperamicin A1
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| CHEBI_ID | CHEBI:53273
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| code | C1301
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| prefixIRI | NCIT:C1301
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| in_subset | |
| Preferred_Name | Esperamicin A1
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| FDA_UNII_Code | PLX8T21X8G
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| Contributing_Source | FDA
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| Maps_To | Esperamicin A1
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| CAS_Registry | 99674-26-7
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| NSC Number | 372668
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| Legacy Concept Name | Esperamicin_A1
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0082481
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