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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1300
http://purl.obolibrary.org/obo/NCIT_C1300
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|---|---|
| Preferred Name | Dolastatin 10 |
| Definitions |
A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04) |
|---|---|
| label | Dolastatin 10
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| prefLabel | Dolastatin 10
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| Legacy Concept Name | Dolastatin_10
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| in_subset |
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| Preferred_Name | Dolastatin 10
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| Is_Value_For_GDC_Property | |
| Display_Name | Dolastatin 10
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| Maps_To | Dolastatin 10
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| PDQ_Open_Trial_Search_ID | 42316
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| UMLS_CUI | C0082338
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| FDA_UNII_Code | EI946JT51X
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| prefixIRI | NCIT:C1300
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| NCI_Drug_Dictionary_ID | 42316
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C1300
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It binds to a protein that cells need to divide and it may kill cancer cells. Dolastatin 10 comes from a marine organism. It is a type of mitotic inhibitor.
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| NSC Number | 376128
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| PDQ_Closed_Trial_Search_ID | 42316
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| CAS_Registry | 110417-88-4
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