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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1298
http://purl.obolibrary.org/obo/NCIT_C1298
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|---|---|
| Preferred Name | O-Chloroacetylcarbamoylfumagillol |
| Definitions |
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04) |
|---|---|
| prefLabel | O-Chloroacetylcarbamoylfumagillol
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| label | O-Chloroacetylcarbamoylfumagillol
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| PDQ_Closed_Trial_Search_ID | 41725
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| code | C1298
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| prefixIRI | NCIT:C1298
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| in_subset | |
| Preferred_Name | O-Chloroacetylcarbamoylfumagillol
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| FDA_UNII_Code | X47GR46481
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| Contributing_Source | FDA
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| Maps_To | O-Chloroacetylcarbamoylfumagillol
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| CAS_Registry | 129298-91-5
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| NSC Number | 642492
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| NCI_Drug_Dictionary_ID | 41725
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| Legacy Concept Name | TNP-470
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41725
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0081489
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