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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C129710
http://purl.obolibrary.org/obo/NCIT_C129710
|
|---|---|
| Preferred Name | BTK Inhibitor M7583 |
| Definitions |
An orally bioavailable, selective inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, M7583 targets and covalently binds to BTK, thereby preventing its activity. This leads to an inhibition of B cell receptor (BCR) signaling and inhibits cell proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, selective inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, M7583 targets and covalently binds to BTK, thereby preventing its activity. This leads to an inhibition of B cell receptor (BCR) signaling and inhibits cell proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. |
|---|---|
| prefLabel | BTK Inhibitor M7583
|
| label | BTK Inhibitor M7583
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| NCI_META_CUI | CL512935
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| PDQ_Closed_Trial_Search_ID | 784381
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| code | C129710
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| Has_Target | |
| prefixIRI | NCIT:C129710
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| in_subset | |
| Preferred_Name | BTK Inhibitor M7583
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| Maps_To | BTK Inhibitor M7583
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| NCI_Drug_Dictionary_ID | 784381
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 784381
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| Semantic_Type | Pharmacologic Substance
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