Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C129688
http://purl.obolibrary.org/obo/NCIT_C129688
|
|---|---|
| Preferred Name | CSF1R Inhibitor PLX73086 |
| Definitions |
An inhibitor of colony stimulating factor 1 receptor (CSF1R; CSF-1R), with potential antineoplastic activity. Upon administration, CSF1R inhibitor PLX73086 targets and binds to CSF1R, thereby blocking CSF1R activation and CSF1R-mediated signaling. This inhibits the activity of tumor-associated macrophages (TAMs) in the tumor tissue and prevents TAM-related tumor cell growth. CSF1R, also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor for its ligand colony stimulating factor 1 (CSF1) and plays major roles in tumor cell proliferation and metastasis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of colony stimulating factor 1 receptor (CSF1R; CSF-1R), with potential antineoplastic activity. Upon administration, CSF1R inhibitor PLX73086 targets and binds to CSF1R, thereby blocking CSF1R activation and CSF1R-mediated signaling. This inhibits the activity of tumor-associated macrophages (TAMs) in the tumor tissue and prevents TAM-related tumor cell growth. CSF1R, also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor for its ligand colony stimulating factor 1 (CSF1) and plays major roles in tumor cell proliferation and metastasis. |
|---|---|
| prefLabel | CSF1R Inhibitor PLX73086
|
| label | CSF1R Inhibitor PLX73086
|
| NCI_META_CUI | CL507868
|
| code | C129688
|
| Has_Target | |
| prefixIRI | NCIT:C129688
|
| in_subset | |
| Display_Name | CSF1R Inhibitor PLX73086
|
| Preferred_Name | CSF1R Inhibitor PLX73086
|
| Contributing_Source | CTRP
|
| Maps_To | CSF1R Inhibitor PLX73086
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |