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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C128557
http://purl.obolibrary.org/obo/NCIT_C128557
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|---|---|
| Preferred Name | Topoisomerase I/II Inhibitor NEV-801 |
| Definitions |
A multi-targeted agent with potential antineoplastic activity. Upon administration, NEV-801 appears to selectively inhibit topoisomerase (Topo) I and II, and activates hypoxia-inducible factor 1 (HIF-1) transcription and the expression of vascular endothelial growth factor (VEGF) mRNA. NEV-801 is also able to overcome multidrug resistance (MDR) 1-mediated resistance.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A multi-targeted agent with potential antineoplastic activity. Upon administration, NEV-801 appears to selectively inhibit topoisomerase (Topo) I and II, and activates hypoxia-inducible factor 1 (HIF-1) transcription and the expression of vascular endothelial growth factor (VEGF) mRNA. NEV-801 is also able to overcome multidrug resistance (MDR) 1-mediated resistance. |
|---|---|
| prefLabel | Topoisomerase I/II Inhibitor NEV-801
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| label | Topoisomerase I/II Inhibitor NEV-801
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| NCI_META_CUI | CL507943
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| PDQ_Closed_Trial_Search_ID | 782337
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| code | C128557
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| Has_Target | |
| prefixIRI | NCIT:C128557
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| in_subset |
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| Display_Name | Topoisomerase I/II Inhibitor NEV-801
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| Preferred_Name | Topoisomerase I/II Inhibitor NEV-801
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| Contributing_Source | CTRP
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| Maps_To | Topoisomerase I/II Inhibitor NEV-801
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| NCI_Drug_Dictionary_ID | 782337
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 782337
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| Semantic_Type | Pharmacologic Substance
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