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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C128107
http://purl.obolibrary.org/obo/NCIT_C128107
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|---|---|
| Preferred Name | Nemvaleukin Alfa |
| Definitions |
A selective effector cell activator protein and agonist of the intermediate-affinity interleukin-2 (IL-2) receptor with potential immunostimulating and antineoplastic activity. Upon administration, nemvaleukin alfa binds to and signals through the intermediate-affinity IL-2 receptor complex; this may selectively stimulate and activate natural killer (NK) cells and memory CD8 T-cells, leading to tumor cell elimination, while circumventing the activation of immunosuppressive cells that may prevent the anti-tumor response. IL-2 is a cytokine signaling molecule that plays a critical role in the immune response.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A selective effector cell activator protein and agonist of the intermediate-affinity interleukin-2 (IL-2) receptor with potential immunostimulating and antineoplastic activity. Upon administration, nemvaleukin alfa binds to and signals through the intermediate-affinity IL-2 receptor complex; this may selectively stimulate and activate natural killer (NK) cells and memory CD8 T-cells, leading to tumor cell elimination, while circumventing the activation of immunosuppressive cells that may prevent the anti-tumor response. IL-2 is a cytokine signaling molecule that plays a critical role in the immune response. |
|---|---|
| prefLabel | Nemvaleukin Alfa
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| label | Nemvaleukin Alfa
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| NCI_META_CUI | CL507938
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| PDQ_Closed_Trial_Search_ID | 782089
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| code | C128107
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| prefixIRI | NCIT:C128107
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| in_subset |
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| Display_Name | Nemvaleukin Alfa
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| Preferred_Name | Nemvaleukin Alfa
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| FDA_UNII_Code | 7ZX1Q9SJ1F
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Intermediate-affinity Interleukin-2 Receptor Agonist ALKS 4230
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| CAS_Registry | 2315268-27-8
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| NCI_Drug_Dictionary_ID | 782089
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 782089
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| Semantic_Type | Pharmacologic Substance
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