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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1276
http://purl.obolibrary.org/obo/NCIT_C1276
|
|---|---|
| Preferred Name | Vinzolidine |
| Definitions |
An orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase. |
|---|---|
| prefLabel | Vinzolidine
|
| label | Vinzolidine
|
| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 39733
|
| code | C1276
|
| prefixIRI | NCIT:C1276
|
| in_subset | |
| Preferred_Name | Vinzolidine
|
| FDA_UNII_Code | 533U947V6Q
|
| Contributing_Source | FDA
|
| Chemical_Formula | C48H58ClN5O9
|
| Maps_To | Vinzolidine
|
| CAS_Registry | 67699-40-5
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| NCI_Drug_Dictionary_ID | 39733
|
| Legacy Concept Name | Vinzolidine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39733
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0078282
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| Delete | Subject | Author | Type | Created |
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