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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1275
http://purl.obolibrary.org/obo/NCIT_C1275
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|---|---|
| Preferred Name | Vinorelbine |
| Definitions |
A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
|---|---|
| prefLabel | Vinorelbine
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| label | Vinorelbine
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:480999
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| code | C1275
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| Has_Target | |
| prefixIRI | NCIT:C1275
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| in_subset |
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| Display_Name | Vinorelbine
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| Preferred_Name | Vinorelbine
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| FDA_UNII_Code | Q6C979R91Y
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| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C45H54N4O8
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| Maps_To | Vinorelbine
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| CAS_Registry | 71486-22-1
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| Legacy Concept Name | Vinorelbine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Accepted_Therapeutic_Use_For | Breast cancer; Cervical cancer; Non-small cell lung cancer; Ovarian cancer; Prostate cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0078257
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