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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1271
http://purl.obolibrary.org/obo/NCIT_C1271
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|---|---|
| Preferred Name | 7-Hydroxystaurosporine |
| Definitions |
A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04) |
|---|---|
| prefLabel | 7-Hydroxystaurosporine
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| label | 7-Hydroxystaurosporine
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| PDQ_Closed_Trial_Search_ID | 42305
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| code | C1271
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| Has_Target | |
| prefixIRI | NCIT:C1271
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| in_subset |
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| Display_Name | 7-Hydroxystaurosporine
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| Preferred_Name | 7-Hydroxystaurosporine
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| FDA_UNII_Code | 7BU5H4V94A
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C28H26N4O4
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| Maps_To | 7-Hydroxystaurosporine
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| CAS_Registry | 112953-11-4
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| NSC Number | 638850
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| NCI_Drug_Dictionary_ID | 42305
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| Legacy Concept Name | _7-Hydroxystaurosporine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called staurosporine analogues.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42305
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0077681
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