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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1268
http://purl.obolibrary.org/obo/NCIT_C1268
|
|---|---|
| Preferred Name | Trofosfamide |
| Definitions |
An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis. |
|---|---|
| prefLabel | Trofosfamide
|
| label | Trofosfamide
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| PDQ_Closed_Trial_Search_ID | 39725
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| code | C1268
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| prefixIRI | NCIT:C1268
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| in_subset | |
| Preferred_Name | Trofosfamide
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| FDA_UNII_Code | H64JRU6GJ0
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| Contributing_Source | FDA
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| Chemical_Formula | C9H18Cl3N2O2P
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| Maps_To | Trofosfamide
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| CAS_Registry | 22089-22-1
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| NSC Number | 109723
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| NCI_Drug_Dictionary_ID | 39725
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| Legacy Concept Name | Trofosfamide
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39725
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0077375
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| Delete | Subject | Author | Type | Created |
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