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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C126794
http://purl.obolibrary.org/obo/NCIT_C126794
|
|---|---|
| Preferred Name | Anti-LGR5 Monoclonal Antibody BNC101 |
| Definitions |
A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby inhibiting LRG5-mediated signal transduction pathways. This prevents proliferation of LRG5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby inhibiting LRG5-mediated signal transduction pathways. This prevents proliferation of LRG5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival. |
|---|---|
| prefLabel | Anti-LGR5 Monoclonal Antibody BNC101
|
| label | Anti-LGR5 Monoclonal Antibody BNC101
|
| NCI_META_CUI | CL507886
|
| PDQ_Closed_Trial_Search_ID | 780067
|
| code | C126794
|
| prefixIRI | NCIT:C126794
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| in_subset | |
| Preferred_Name | Anti-LGR5 Monoclonal Antibody BNC101
|
| Maps_To | Anti-LGR5 Monoclonal Antibody BNC101
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| NCI_Drug_Dictionary_ID | 780067
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 780067
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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