Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Fluoroquinolone Antibiotic
Synonyms
Definitions

Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation.
ID

http://purl.obolibrary.org/obo/NCIT_C126712
code

C126712
Contributing_Source

CTRP
definition

Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation.
Display_Name

Fluoroquinolone Antibiotic
in_subset

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978
label

Fluoroquinolone Antibiotic
Preferred_Name

Fluoroquinolone Antibiotic
prefixIRI

NCIT:C126712
prefLabel

Fluoroquinolone Antibiotic
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C0949665
subClassOf

http://purl.obolibrary.org/obo/NCIT_C795
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