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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C126644
http://purl.obolibrary.org/obo/NCIT_C126644
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|---|---|
| Preferred Name | Anti-VEGF/ANG2 Nanobody BI 836880 |
| Definitions |
A nanobody directed against angiopoietin-2 (Ang2; ANGPT2)- and vascular endothelial growth factor (VEGF)-derived peptides, with potential antiangiogenic and antineoplastic activities. Anti-VEGF/ANG2 nanobody BI 836880 binds to Ang2 and VEGF and inhibits receptor binding; this prevents Ang2- and VEGF-mediated signaling and inhibits both tumor angiogenesis and tumor cell proliferation. Both VEGF and Ang2 are upregulated in a variety of cancer cell types and play a crucial role in angiogenesis. The nanobody is based on functional fragments of single-chain antibodies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A nanobody directed against angiopoietin-2 (Ang2; ANGPT2)- and vascular endothelial growth factor (VEGF)-derived peptides, with potential antiangiogenic and antineoplastic activities. Anti-VEGF/ANG2 nanobody BI 836880 binds to Ang2 and VEGF and inhibits receptor binding; this prevents Ang2- and VEGF-mediated signaling and inhibits both tumor angiogenesis and tumor cell proliferation. Both VEGF and Ang2 are upregulated in a variety of cancer cell types and play a crucial role in angiogenesis. The nanobody is based on functional fragments of single-chain antibodies. |
|---|---|
| prefLabel | Anti-VEGF/ANG2 Nanobody BI 836880
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| label | Anti-VEGF/ANG2 Nanobody BI 836880
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| NCI_META_CUI | CL503761
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| PDQ_Closed_Trial_Search_ID | 779752
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| code | C126644
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| Has_Target | |
| prefixIRI | NCIT:C126644
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| in_subset |
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| Display_Name | Anti-VEGF/ANG2 Nanobody BI 836880
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| Preferred_Name | Anti-VEGF/ANG2 Nanobody BI 836880
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| FDA_UNII_Code | IS7N1X9TSW
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-VEGF/ANG2 Nanobody BI 836880
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| CAS_Registry | 2254603-60-4
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| NCI_Drug_Dictionary_ID | 779752
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 779752
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| Semantic_Type | Pharmacologic Substance
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