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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1266
http://purl.obolibrary.org/obo/NCIT_C1266
|
|---|---|
| Preferred Name | Trioxifene |
| Definitions |
A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen. |
|---|---|
| prefLabel | Trioxifene
|
| label | Trioxifene
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 39726
|
| code | C1266
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| prefixIRI | NCIT:C1266
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| in_subset | |
| Preferred_Name | Trioxifene
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| FDA_UNII_Code | R0130F043H
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| Contributing_Source | FDA
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| Chemical_Formula | C30H31NO3
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| Maps_To | Trioxifene
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| CAS_Registry | 63619-84-1
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| NCI_Drug_Dictionary_ID | 39726
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| Legacy Concept Name | Trioxifene
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39726
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0077238
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| Delete | Subject | Author | Type | Created |
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