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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1265
http://purl.obolibrary.org/obo/NCIT_C1265
|
|---|---|
| Preferred Name | Trimetrexate Glucuronate |
| Definitions |
A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04) |
|---|---|
| prefLabel | Trimetrexate Glucuronate
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| label | Trimetrexate Glucuronate
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| PDQ_Closed_Trial_Search_ID | 39764
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| code | C1265
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| prefixIRI | NCIT:C1265
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| in_subset | |
| Preferred_Name | Trimetrexate Glucuronate
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| FDA_UNII_Code | L137U4A79K
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| Contributing_Source | FDA
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| Chemical_Formula | C19H23N5O3.C6H10O7
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| Maps_To | Trimetrexate Glucuronate
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| CAS_Registry | 82952-64-5
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| NSC Number | 352122
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| NCI_Drug_Dictionary_ID | 39764
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| Legacy Concept Name | Trimetrexate_Glucuronate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39764
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| Accepted_Therapeutic_Use_For | Head and neck cancer; Metastatic colorectal adenocarcinoma; Non-small cell lung cancer; Osteogenic sarcoma; Pancreatic adenocarcinoma; Pneumocystitis carinii pneumonia
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0077209
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