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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C126334
http://purl.obolibrary.org/obo/NCIT_C126334
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|---|---|
| Preferred Name | Anti-FGFR4 Monoclonal Antibody U3-1784 |
| Definitions |
A human monoclonal antibody against human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, U3-1784 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A human monoclonal antibody against human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, U3-1784 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival. |
|---|---|
| prefLabel | Anti-FGFR4 Monoclonal Antibody U3-1784
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| label | Anti-FGFR4 Monoclonal Antibody U3-1784
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| NCI_META_CUI | CL504900
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| PDQ_Closed_Trial_Search_ID | 779617
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| code | C126334
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| Has_Target | |
| prefixIRI | NCIT:C126334
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| in_subset | |
| Preferred_Name | Anti-FGFR4 Monoclonal Antibody U3-1784
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| Maps_To | Anti-FGFR4 Monoclonal Antibody U3-1784
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| NCI_Drug_Dictionary_ID | 779617
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 779617
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| Semantic_Type | Pharmacologic Substance
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