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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1262
http://purl.obolibrary.org/obo/NCIT_C1262
|
|---|---|
| Preferred Name | Triciribine Phosphate |
| Definitions |
The phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9. |
|---|---|
| prefLabel | Triciribine Phosphate
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| label | Triciribine Phosphate
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| PDQ_Closed_Trial_Search_ID | 39723
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| code | C1262
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| Has_Target | |
| prefixIRI | NCIT:C1262
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| in_subset |
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| Display_Name | Triciribine Phosphate
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| Preferred_Name | Triciribine Phosphate
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| FDA_UNII_Code | 5L5GE3DV88
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C13H17N6O7P
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| Maps_To | Triciribine Phosphate
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| CAS_Registry | 61966-08-3
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| NSC Number | 280594
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| NCI_Drug_Dictionary_ID | 39723
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| Legacy Concept Name | Triciribine_Phosphate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39723
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0077070
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