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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C126113
http://purl.obolibrary.org/obo/NCIT_C126113
|
|---|---|
| Preferred Name | Zalifrelimab |
| Definitions |
A recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint inhibitory and antineoplastic activities. Upon administration, zalifrelimab binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint inhibitory and antineoplastic activities. Upon administration, zalifrelimab binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. |
|---|---|
| prefLabel | Zalifrelimab
|
| label | Zalifrelimab
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| NCI_META_CUI | CL504706
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| PDQ_Closed_Trial_Search_ID | 779578
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| code | C126113
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| Has_Target | |
| prefixIRI | NCIT:C126113
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| in_subset |
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| Display_Name | Zalifrelimab
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| Preferred_Name | Zalifrelimab
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| FDA_UNII_Code | FE7L22H028
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Zalifrelimab
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| CAS_Registry | 2148321-69-9
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| NCI_Drug_Dictionary_ID | 779578
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 779578
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| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
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| Delete | Subject | Author | Type | Created |
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