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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1260
http://purl.obolibrary.org/obo/NCIT_C1260
|
|---|---|
| Preferred Name | Tributyrin |
| Definitions |
A triglyceride prodrug of butyric acid with potential antineoplastic activity. Butyrate, the active metabolite of tributyrin, inhibits histone deacetylase, resulting in increased differentiation, decreased proliferation, cell cycle arrest, and apoptosis in some tumor cell lines. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A triglyceride prodrug of butyric acid with potential antineoplastic activity. Butyrate, the active metabolite of tributyrin, inhibits histone deacetylase, resulting in increased differentiation, decreased proliferation, cell cycle arrest, and apoptosis in some tumor cell lines. (NCI04) |
|---|---|
| prefLabel | Tributyrin
|
| label | Tributyrin
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| PDQ_Closed_Trial_Search_ID | 42290
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| code | C1260
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| prefixIRI | NCIT:C1260
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| in_subset | |
| Preferred_Name | Tributyrin
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| FDA_UNII_Code | S05LZ624MF
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| Contributing_Source | FDA
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| Chemical_Formula | C15H26O6
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| Maps_To | Tributyrin
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| CAS_Registry | 60-01-5
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| NSC Number | 661583
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| NCI_Drug_Dictionary_ID | 42290
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| Legacy Concept Name | Tributyrin
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| type | |
| ALT_DEFINITION | A triglyceride drug that may inhibit cell growth and induce cell differentiation. Differentiating agents may be effective in changing cancer cells back into normal cells.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42290
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0077025
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| Delete | Subject | Author | Type | Created |
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