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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C125607
http://purl.obolibrary.org/obo/NCIT_C125607
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|---|---|
| Preferred Name | P-cadherin-targeting Agent PF-06671008 |
| Definitions |
An agent that targets p-cadherin (CDH3), with potential antineoplastic activity. Upon administration, PF-06671008 binds to and inhibits the activity of p-cadherin; this may inhibit both invasion and proliferation of p-cadherin expressing tumor cells. P-cadherin, a cell-surface protein and member of the cadherin family, is overexpressed in a variety of tumors and plays a role in cell adhesion, motility, invasion, and proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An agent that targets p-cadherin (CDH3), with potential antineoplastic activity. Upon administration, PF-06671008 binds to and inhibits the activity of p-cadherin; this may inhibit both invasion and proliferation of p-cadherin expressing tumor cells. P-cadherin, a cell-surface protein and member of the cadherin family, is overexpressed in a variety of tumors and plays a role in cell adhesion, motility, invasion, and proliferation. |
|---|---|
| prefLabel | P-cadherin-targeting Agent PF-06671008
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| label | P-cadherin-targeting Agent PF-06671008
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| NCI_META_CUI | CL504311
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| PDQ_Closed_Trial_Search_ID | 778591
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| code | C125607
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| prefixIRI | NCIT:C125607
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| in_subset |
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| Display_Name | P-cadherin-targeting Agent PF-06671008
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| Preferred_Name | P-cadherin-targeting Agent PF-06671008
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| FDA_UNII_Code | 2GWZ8HN70W
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| Contributing_Source |
CTRP
FDA
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| Maps_To | P-cadherin-targeting Agent PF-06671008
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| NCI_Drug_Dictionary_ID | 778591
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 778591
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| Semantic_Type | Pharmacologic Substance
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