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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1254
http://purl.obolibrary.org/obo/NCIT_C1254
|
|---|---|
| Preferred Name | Tiazofurin |
| Definitions |
A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. (NCI04) |
|---|---|
| prefLabel | Tiazofurin
|
| label | Tiazofurin
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| PDQ_Closed_Trial_Search_ID | 39717
|
| code | C1254
|
| prefixIRI | NCIT:C1254
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| in_subset | |
| Preferred_Name | Tiazofurin
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| FDA_UNII_Code | ULJ82834RE
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| Contributing_Source | FDA
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| Chemical_Formula | C9H12N2O5S
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| Maps_To | Tiazofurin
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| CAS_Registry | 60084-10-8
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| NSC Number | 286193
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| NCI_Drug_Dictionary_ID | 39717
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| Legacy Concept Name | Tiazofurin
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| type | |
| ALT_DEFINITION | An anticancer drug being studied to stop cell growth.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39717
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0076656
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