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Biological and Environmental Research Ontology
| Preferred Name | Topical Fluorouracil | |
| Synonyms |
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| Definitions |
A topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C125194 |
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| code |
C125194
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| Contributing_Source |
CTRP
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| definition |
A topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally.
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| Display_Name |
Topical Fluorouracil
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Topical Fluorouracil
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| Maps_To |
Topical Fluorouracil
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| NCI_Drug_Dictionary_ID |
777929
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| PDQ_Closed_Trial_Search_ID |
777929
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| PDQ_Open_Trial_Search_ID |
777929
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| Preferred_Name |
Topical Fluorouracil
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| prefixIRI |
NCIT:C125194
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| prefLabel |
Topical Fluorouracil
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI |
C0720488
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125194 | NCIT | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000777929 | PDQ | LOOM |