Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Topical Fluorouracil
Synonyms
Definitions

A topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally.
ID

http://purl.obolibrary.org/obo/NCIT_C125194
code

C125194
Contributing_Source

CTRP
definition

A topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally.
Display_Name

Topical Fluorouracil
Has_Target

http://purl.obolibrary.org/obo/NCIT_C17199
in_subset

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712
Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909
label

Topical Fluorouracil
Maps_To

Topical Fluorouracil
NCI_Drug_Dictionary_ID

777929
PDQ_Closed_Trial_Search_ID

777929
PDQ_Open_Trial_Search_ID

777929
Preferred_Name

Topical Fluorouracil
prefixIRI

NCIT:C125194
prefLabel

Topical Fluorouracil
Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI

C0720488
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1557

http://purl.obolibrary.org/obo/NCIT_C2021
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