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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C124996
http://purl.obolibrary.org/obo/NCIT_C124996
|
|---|---|
| Preferred Name | Iodine I 131 Tenatumomab |
| Definitions |
A radioimmunoconjugate of tenatumomab, a murine monoclonal antibody targeting the tumor-associated antigen (TAA) tenascin-C (TNC), labeled with iodine I 131, with potential antineoplastic activity. The antibody moiety of iodine I 131 tenatumomab binds to TNC, thereby delivering a cytotoxic dose of iodine I 131 specifically to tumors expressing TNC. TNC, an extracellular matrix protein, is upregulated in a variety of tumor cell types; it plays a key role in invasion, tumor cell proliferation and immune evasion.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate of tenatumomab, a murine monoclonal antibody targeting the tumor-associated antigen (TAA) tenascin-C (TNC), labeled with iodine I 131, with potential antineoplastic activity. The antibody moiety of iodine I 131 tenatumomab binds to TNC, thereby delivering a cytotoxic dose of iodine I 131 specifically to tumors expressing TNC. TNC, an extracellular matrix protein, is upregulated in a variety of tumor cell types; it plays a key role in invasion, tumor cell proliferation and immune evasion. |
|---|---|
| prefLabel | Iodine I 131 Tenatumomab
|
| label | Iodine I 131 Tenatumomab
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| NCI_META_CUI | CL503842
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| PDQ_Closed_Trial_Search_ID | 777273
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| code | C124996
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| prefixIRI | NCIT:C124996
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| in_subset | |
| Preferred_Name | Iodine I 131 Tenatumomab
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| Maps_To | Iodine I 131 Tenatumomab
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| NCI_Drug_Dictionary_ID | 777273
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 777273
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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