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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1239
http://purl.obolibrary.org/obo/NCIT_C1239
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|---|---|
| Preferred Name | Exisulind |
| Definitions |
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive biotransformation including irreversible oxidation to sulindac sulfone. Approximately, one half of an administered dose of sulindac is eliminated through the urine, mostly as the conjugated sulfone metabolite. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive biotransformation including irreversible oxidation to sulindac sulfone. Approximately, one half of an administered dose of sulindac is eliminated through the urine, mostly as the conjugated sulfone metabolite. (NCI04) |
|---|---|
| prefLabel | Exisulind
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| label | Exisulind
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| CHEBI_ID | CHEBI:64212
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| PDQ_Closed_Trial_Search_ID | 43057
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| code | C1239
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| Has_Target | |
| prefixIRI | NCIT:C1239
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| in_subset |
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| Display_Name | Exisulind
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| Preferred_Name | Exisulind
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| FDA_UNII_Code | K619IIG2R9
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C20H17FO4S
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| Maps_To | Exisulind
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| CAS_Registry | 59973-80-7
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| NSC Number | 719619
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| NCI_Drug_Dictionary_ID | 43057
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| Legacy Concept Name | Sulindac_Sulfone
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| type | |
| ALT_DEFINITION | A drug being studied in the treatment and prevention of cancer. It has been shown to cause apoptosis (cell death) in cells that are malignant (cancer) and in cells that may become cancer. It acts through a group of cellular enzymes called cGMP phosphodiesterases.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43057
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| Accepted_Therapeutic_Use_For | Colonic adenomatous polyps in the inherited disease adenomatous polyposis coli, control and suppression
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0075616
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