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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C123722
http://purl.obolibrary.org/obo/NCIT_C123722
|
|---|---|
| Preferred Name | EGFR Antagonist Hemay022 |
| Definitions |
An orally available, irreversible inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, Hemay022 covalently binds to and inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available, irreversible inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, Hemay022 covalently binds to and inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. |
|---|---|
| prefLabel | EGFR Antagonist Hemay022
|
| label | EGFR Antagonist Hemay022
|
| PDQ_Closed_Trial_Search_ID | 775380
|
| code | C123722
|
| Has_Target | |
| prefixIRI | NCIT:C123722
|
| in_subset | |
| Preferred_Name | EGFR Antagonist Hemay022
|
| Maps_To | EGFR Antagonist Hemay022
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| NCI_Drug_Dictionary_ID | 775380
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 775380
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C4053636
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