Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C123380
http://purl.obolibrary.org/obo/NCIT_C123380
|
|---|---|
| Preferred Name | Anti-CD123 Monoclonal Antibody KHK2823 |
| Definitions |
A fully human monoclonal antibody against CD123 (interleukin-3 receptor alpha chain) with potential antineoplastic activity. Anti-CD123 monoclonal antibody KHK2823 binds to and neutralizes CD123, which is upregulated on leukemic stem cells (LSC) found in myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). This agent may inhibit IL-3-dependent signaling and proliferation and may prevent the uncontrolled growth and differentiation of mutated LSC.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A fully human monoclonal antibody against CD123 (interleukin-3 receptor alpha chain) with potential antineoplastic activity. Anti-CD123 monoclonal antibody KHK2823 binds to and neutralizes CD123, which is upregulated on leukemic stem cells (LSC) found in myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). This agent may inhibit IL-3-dependent signaling and proliferation and may prevent the uncontrolled growth and differentiation of mutated LSC. |
|---|---|
| prefLabel | Anti-CD123 Monoclonal Antibody KHK2823
|
| label | Anti-CD123 Monoclonal Antibody KHK2823
|
| NCI_META_CUI | CL474096
|
| PDQ_Closed_Trial_Search_ID | 762775
|
| code | C123380
|
| prefixIRI | NCIT:C123380
|
| in_subset | |
| Preferred_Name | Anti-CD123 Monoclonal Antibody KHK2823
|
| Maps_To | Anti-CD123 Monoclonal Antibody KHK2823
|
| NCI_Drug_Dictionary_ID | 762775
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 762775
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |