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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1233
http://purl.obolibrary.org/obo/NCIT_C1233
|
|---|---|
| Preferred Name | Spiromustine |
| Definitions |
A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04) |
|---|---|
| prefLabel | Spiromustine
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| label | Spiromustine
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| PDQ_Closed_Trial_Search_ID | 39441
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| code | C1233
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| prefixIRI | NCIT:C1233
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| in_subset | |
| Preferred_Name | Spiromustine
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| FDA_UNII_Code | J3HB83X76Z
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| Contributing_Source | FDA
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| Maps_To | Spiromustine
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| CAS_Registry | 56605-16-4
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| NSC Number | 172112
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| NCI_Drug_Dictionary_ID | 39441
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| Legacy Concept Name | Spiromustine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39441
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0075019
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