Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C1224 http://purl.obolibrary.org/obo/NCIT_C1224
Preferred Name	Atamestane
Definitions	A synthetic steroidal substance with antineoplastic activity. Atamestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic steroidal substance with antineoplastic activity. Atamestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)
prefLabel	Atamestane
label	Atamestane
PDQ_Closed_Trial_Search_ID	38195
code	C1224
prefixIRI	NCIT:C1224
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Atamestane
FDA_UNII_Code	62GA3K28B6
Contributing_Source	FDA
Chemical_Formula	C20H26O2
Maps_To	Atamestane
CAS_Registry	96301-34-7
NCI_Drug_Dictionary_ID	38195
Legacy Concept Name	Atamestane
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A substance that is being studied in the treatment of cancer. Atamestane blocks the production of the hormone estrogen in the body. It belongs to the family of drugs called antiestrogens.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C2017
PDQ_Open_Trial_Search_ID	38195
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C0074442

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