loading...| Preferred Name | Samarium Sm-153 Lexidronam Pentasodium | |
| Synonyms |
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| Definitions |
The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1220 |
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| ALT_DEFINITION |
A drug used to treat pain caused by bone cancer and other cancers that have spread to the bones. Samarium Sm 153 lexidronam pentasodium is a type of radiopharmaceutical. |
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| CAS_Registry |
160369-78-8 |
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| Chemical_Formula |
C6H12N2O12P4.5Na.Sm |
|
| code |
C1220 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases. |
|
| Display_Name |
Samarium Sm-153 Lexidronam Pentasodium |
|
| FDA_UNII_Code |
7389YR3OOV |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Samarium Sm-153 Lexidronam Pentasodium |
|
| Legacy Concept Name |
Sm_153_Lexidronam_Pentasodium |
|
| NCI_Drug_Dictionary_ID |
42245 |
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| NSC Number |
741196 |
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| PDQ_Closed_Trial_Search_ID |
42245 |
|
| PDQ_Open_Trial_Search_ID |
42245 |
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| Preferred_Name |
Samarium Sm-153 Lexidronam Pentasodium |
|
| prefixIRI |
NCIT:C1220 |
|
| prefLabel |
Samarium Sm-153 Lexidronam Pentasodium |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0772051 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/RXNORM/317675 | RXNORM | LOOM | |
| http://purl.bioontology.org/ontology/PDQ/CDR0000042245 | PDQ | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1220 | NCIT | LOOM |