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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C121927
http://purl.obolibrary.org/obo/NCIT_C121927
|
|---|---|
| Preferred Name | Ivuxolimab |
| Definitions |
An agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134; TNFRSF4), with potential immunostimulatory activity. Upon administration, ivuxolimab selectively binds to and activates OX40; which induces proliferation of memory and effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote a T-cell-mediated immune response against TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134; TNFRSF4), with potential immunostimulatory activity. Upon administration, ivuxolimab selectively binds to and activates OX40; which induces proliferation of memory and effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote a T-cell-mediated immune response against TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation. |
|---|---|
| prefLabel | Ivuxolimab
|
| label | Ivuxolimab
|
| PDQ_Closed_Trial_Search_ID | 767326
|
| code | C121927
|
| Has_Target | |
| prefixIRI | NCIT:C121927
|
| in_subset |
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| Display_Name | Ivuxolimab
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| Preferred_Name | Ivuxolimab
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| FDA_UNII_Code | APS3IS9D6W
|
| Contributing_Source |
CTRP
FDA
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| Maps_To |
Anti-OX40 Agonist Monoclonal Antibody PF-04518600
Ivuxolimab
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| CAS_Registry | 2128729-41-7
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| NCI_Drug_Dictionary_ID | 767326
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 767326
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C4053606
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