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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C121856
http://purl.obolibrary.org/obo/NCIT_C121856
|
|---|---|
| Preferred Name | Autologous Dendritic Cell Vaccine ACT2001 |
| Definitions |
A cell-based cancer vaccine composed of autologous, immature dendritic cells (DCs), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, immature DCs are isolated and re-administered intra-tumorally. The immature DCs internalize and process the tumor-associated antigens (TAAs), migrate to the lymphatic system, and then expose the immune system to the TAAs. This induces a specific cytotoxic T-lymphocyte (CTL) response against the cancer cells leading to tumor cell lysis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cell-based cancer vaccine composed of autologous, immature dendritic cells (DCs), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, immature DCs are isolated and re-administered intra-tumorally. The immature DCs internalize and process the tumor-associated antigens (TAAs), migrate to the lymphatic system, and then expose the immune system to the TAAs. This induces a specific cytotoxic T-lymphocyte (CTL) response against the cancer cells leading to tumor cell lysis. |
|---|---|
| prefLabel | Autologous Dendritic Cell Vaccine ACT2001
|
| label | Autologous Dendritic Cell Vaccine ACT2001
|
| PDQ_Closed_Trial_Search_ID | 771721
|
| code | C121856
|
| prefixIRI | NCIT:C121856
|
| in_subset | |
| Preferred_Name | Autologous Dendritic Cell Vaccine ACT2001
|
| Maps_To | Autologous Dendritic Cell Vaccine ACT2001
|
| NCI_Drug_Dictionary_ID | 771721
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 771721
|
| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
|
| UMLS_CUI | C4053686
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