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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C121850
http://purl.obolibrary.org/obo/NCIT_C121850
|
|---|---|
| Preferred Name | Cetuximab Sarotalocan Sodium |
| Definitions |
The sodium salt form of cetuximab sarotalocan, which consists of a chemical conjugate composed of the dye IR700 linked to cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon injection of cetuximab sarotalocan sodium, the cetuximab moiety targets and binds to EGFR-expressing tumor cells, resulting in the internalization of the conjugate. Upon localized application of near-infrared (NIR) light, the IR700 dye becomes activated, disrupts the cell membrane and selectively kills the EGFR-expressing tumor cells. EGFR, a tyrosine kinase receptor, is overexpressed in a variety of cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt form of cetuximab sarotalocan, which consists of a chemical conjugate composed of the dye IR700 linked to cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon injection of cetuximab sarotalocan sodium, the cetuximab moiety targets and binds to EGFR-expressing tumor cells, resulting in the internalization of the conjugate. Upon localized application of near-infrared (NIR) light, the IR700 dye becomes activated, disrupts the cell membrane and selectively kills the EGFR-expressing tumor cells. EGFR, a tyrosine kinase receptor, is overexpressed in a variety of cancers. |
|---|---|
| prefLabel | Cetuximab Sarotalocan Sodium
|
| label | Cetuximab Sarotalocan Sodium
|
| PDQ_Closed_Trial_Search_ID | 771602
|
| code | C121850
|
| Has_Target | |
| prefixIRI | NCIT:C121850
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| in_subset |
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| Display_Name | Cetuximab Sarotalocan Sodium
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| Preferred_Name | Cetuximab Sarotalocan Sodium
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| FDA_UNII_Code | MG94W1I5XW
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Cetuximab-IR700 Conjugate RM-1929
Cetuximab Sarotalocan
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| CAS_Registry | 2166339-33-7
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| NCI_Drug_Dictionary_ID | 771602
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 771602
|
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C4053596
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