Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C121828
http://purl.obolibrary.org/obo/NCIT_C121828
Preferred Name

4-Thio-2-deoxycytidine
Definitions
An orally bioavailable 4-thio modified 2-deoxycytidine analog, with potential antineoplastic activity. Upon administration of 4-thio-2-deoxycytidine (TdCyd), this cytidine analog gets incorporated into DNA during replication and inhibits the activity of DNA methyltransferase 1 (DNMT1), which blocks DNA hypermethylation. This results in DNMT1 depletion, hypomethylation of DNA, and the reactivation of tumor suppressor genes that were silenced by hypermethylation; this results in antitumor activity and an inhibition of tumor cell proliferation.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally bioavailable 4-thio modified 2-deoxycytidine analog, with potential antineoplastic activity. Upon administration of 4-thio-2-deoxycytidine (TdCyd), this cytidine analog gets incorporated into DNA during replication and inhibits the activity of DNA methyltransferase 1 (DNMT1), which blocks DNA hypermethylation. This results in DNMT1 depletion, hypomethylation of DNA, and the reactivation of tumor suppressor genes that were silenced by hypermethylation; this results in antitumor activity and an inhibition of tumor cell proliferation.
prefLabel
4-Thio-2-deoxycytidine
label
4-Thio-2-deoxycytidine
PDQ_Closed_Trial_Search_ID
771603
code
C121828
prefixIRI
NCIT:C121828
in_subset
Display_Name
4-Thio-2-deoxycytidine
Preferred_Name
4-Thio-2-deoxycytidine
FDA_UNII_Code
L76O0M313F
Contributing_Source
CTRP
FDA
Maps_To
4-Thio-2-deoxycytidine
CAS_Registry
134111-30-1
NCI_Drug_Dictionary_ID
771603
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
771603
Semantic_Type
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI
C0647434
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